Closing down on an ‘environmental’ miR profile for sAD
After several months of lockdown, the Interreg. VL-NL supported project Herinneringen (Memories) was able to finalize the genetic analyses of human iPSC derived neurons exposed to selected environmental risk factors, and biopties from Alzheimer’s patients and control individuals. Differential gene and pathway analysis revealed processes in patient derived iPSC and biopties that were not seen in material from control individuals. Currently, 9 miR’s have caught out attention for further evaluation.